Do the side effects of cannabis make you sick? The error is possible in your genes ...

"Let's say, though, that the effects of cannabis seemed to like you for a while, but something changed and the effect of THC suddenly seems pushy and unpleasant. What's going on here?"

Factors influencing the effect & effect of hemp

Opioid Receptors: The amount and allocation of opiate receptors in the brain affects the resulting cannabis effect

CB1 receptors and their locations: type of brain cells, which contain most of CB1 receptors, may dictate whether it will experience after cannabis users euphoric , or contrary to it causes aversion

Although it is not advised to interfere with brain development by any drug during adolescence , adolescents are much less sensitive to THC negative effects than adults. In a study comparing the level of negative effects in mouse behavior, adolescent mice were found not to experience as rapid anxiety as in adult mice. A much stronger stress response was observed in adult mice, which researchers measured by monitoring the movement of hormone levels.

However, perhaps even more important is the comparatively higher long-term effect on brain development in adolescent mice. In contrast to adult mice, the brains were adolescent mice affected up to three times more. The most extensive genetic changes have occurred in the hippocampus, ie the brain area is responsiblefunctions such as memory and mood. There were no appreciable changes in adult mice. Thus, this observation suggests that cannabis use during adolescence can lead to permanent changes in brain function development.

Factor 2: The opiate system of the body

The interaction between the endocannabinoid and opiate systems of your body not only results in a degree of functioningcannabinoids as analgesics , but also whether the subject's effect of marijuana seems pleasant or disgusting. Like our body and brain, it contains different types of endocannabinoid receptors (CB1 and CB2), also contains diverse opioid receptors - μ-opioid receptors. and κ- opiate receptors.

activating the μ-opioids ACTIVE receptors leads to subjective feeling of comfort and pleasant satisfaction - these receptors are also responsible for the ability of opioid drugs act against pain. Κ-opioid in contrast, the receptors act in the opposite way, and if the receptor type is over-activated, the opiate effect is also unpleasantly perceived.

the effect of THC in the brain directly affects the amount of endogenous opioid substances, which in turn changes the regulation of mood and processes associated with the perception of emotion on and satisfaction. By observing these mechanisms, the researchers concluded that there may be a fundamental influence between the ratios of the aforementioned opioid receptors, ie: "If multiple µ-opioid receptors are activated, then THC will be beneficial to the person. will feel strange and THC will not. ”

"If we remove genetically κ-opiates in micelang receptors, they begin to return to the THC chambers more often, and the marijuana effect will seem visibly euphoric. ”

Factor 3: CB1 receptors

During one of the last surveys, during which the badatales focused on mapping the mechanism that causes a person's preference or resistance to cannabis, they were at the center ofCB1 receptors. Receptors of this type are known precisely as a key component of the cellular system, which allows us to feel the psychological effects of THC .

The aim of the observation here was the critically important part of the brain responsible for mediating most of the feeling-pleasing effects of drugs - the ventral tegmental area of the brain. Yes, you know right - the ventral tegmental area of the brain produces most of the dopamine . The researchers found that the response may be due to the difference in CB1 receptor location. Some CB1 recipe was found in some mice observedin the excitatory neurons, in other neuron-inhibiting neurons. To understand, excitatory cells stimulate nerve excitement, whereas inhibitory cells stimulate them.

"In mice that had multiple CB1 receptors in the excitatory region, aversive, negative effects of THC were observed, so we can conclude that if THC acts on inhibitory neurons, a more pleasant and euphoric effect occurs."

Human body, THC and erratic reactions

From these results, it could theoretically be concluded that if a person has multiple CB1 receptors in neurons of the excitatory type , then he does not enjoy the effects of THC much and vice versa. But reality is never so simple. Human bodies are an infinitely complex biological complex, and the factors that are ultimately capable of affecting the effect of THC are inexhaustible. The resulting effect of healing cannabis on the individual human body and spirit is always a set of all these factors.