NEW CANNABINOID ON THE SCENE: MEET CBM

Cannabis has been cultivated for thousands of years. But only recently has science begun to reveal its true complexity. To date, we know of several cannabinoids that are present in cannabis, the two most well-known being THC and CBD. It is only recently that a substance called cannabimovone (CBM) has been discovered in the cannabis plant called carmagnola and has been recognised as a cannabinoid with a number of unique effects. What exactly is cannabimovone? In this article, you'll learn everything scientists have discovered about CBM so far.

When was CBM discovered?

Cannabimovone was accidentally discovered in 2010 in an Italian cannabis variety called Carmagnola. However, Kanabimovon has only recently come into the spotlight, when a group of Italian universities and research centres produced a study on the subject in March 2020, which was subsequently published in an issue of the journal Molecules. Their findings showed that this cannabinoid has a different effect toTHC and CBD, despite its similar biological structure to CBD.

How does CBM work?

The formation of organ cells in the human body is primarily controlled by two receptors: PPARa (PPAR-alpha) and PPARy (PPAR-gamma). These cells are also responsible for regulating hormones such as insulin, which plays a vital role in processing the sugars in the diet. CBM has been found to bind to various receptors in the human body , with the highest affinity for the PPARγ receptor. Low insulin regulation leads to metabolic disorders such as diabetes. Scientists say that by activating PPARy receptors, cannabinoids such as CBM could promote proper cell growth as well as hormone regulation to help people with diabetes and similar diseases.

What are the therapeutic effects of CBM?

PPARα and PPARγ receptors regulate the activity of genes that are responsible for cell formation in major human organs such as:

• Heart,
• some muscles,
• kidneys,
• the liver,
• the colon,
• pancreas,
• and spleen.

CBM acts as an agonist of the PPARγ receptor, whereas other cannabinoids, such as THC and CBD, are antagonists of these receptors.

As a PPAR agonist, CBM is absolutely ideal because it can help treat diabetes and other metabolic diseases. Future research on CBM could reveal whether its action on PPARs can be put to good use. Since other cannabinoids, including THC and CBD, are known to affect metabolism, CBM is likely to be included in complex cannabis extracts along with other cannabinoids and terpenes.

Therapeutic effects of cannabinoids

THC: anxiety, cataracts, insomnia, lack of appetite, muscle cramps, nausea, pain and more.

CBD: anxiety, depression, inflammation, migraines, nausea, pain, mental disorders, seizures and more.

CBM: diabetes, metabolic diseases, eating disorders, hormonal disorders, various cancers and other possible effects that have not yet been discovered.

Availability of CBM on the market

CBM comes from a variety of cannabis called Carmagnole, although after further research it is likely that this cannabinoid is also found in other varieties. The relatively high CBM content found in the Carmagnola variety could encourage breeders to crossbreed this variety of industrial hemp with other varieties to produce new varieties with high CBM content. However, cultivation of this variety is probably not yet a good business given that the plant produces only small amounts of this cannabinoid.

Future medical uses of CBM

Since little research has been done on this topic, it is quite difficult to determine exactly how the use of CBM as a medicinal agent will work. Consumers are beginning to see CBM as another component of medicinal cannabis products. While it is true that CBM is too big a novelty to say anything definitive about it, it is also true that what we already know about cannabis may suggest that any future discoveries about CBM are unlikely to be disappointing. And so it is a good time to explore what this new and promising cannabinoid can do. After all, a study published in the journal Molecules revealed that serious health conditions such as diabetes could be treated with new cannabinoid-containing therapies such as CBM, THC, CBD, THCV or other cannabinoids yet to be discovered.

Although CBM is not yet widely available on the market, we will keep you informed of its development. Keep an eye on our website, subscribe to our newsletter and be among the first to hear about its availability.