• We asked the scientist: What is right CBD dose ?

Due to the growing number of researches focusing on the medical use of cannabis compounds, doctors and scientists have managed to bring more light into the issue cannabinoids and their interactions with the human body, but with other cannabinoids. New studies help us understand why these compounds actually work, how they can be most effective and how they can be used in the future.

They talkedwe get withNick Jikomes, court neuroscientistLeaflye, about what researchers are about cannabinoid CBDlearn and how different doses can be used to treat some diseases.

Lets start with the basic question: what exactly is it CBD?

CBD, or cannabidiolis one of the main cannabinoids we can find in cannabis. Right after THC is found in hemp in the most abundant quantity THC it resembles that it is a plant cannabinoid with a similar chemical structure, but there is a big difference between them in terms of physiological effects.

Hland the big difference is that CBD  is not intoxicating. This means that you will not get drunk like that THC. However, when these two substances interact, they can produce different effects. They can enrich each other, but also weaken. And some interactions may be interesting in terms of medical use.

What we already know about the relationship between THCand CBD and what we are at the bottom of it

The most important thing is to understand how each of these compounds reacts with our nervous system receptors. The main endocannabinoid receptor (ECS) receptor responsible for the psychoactive effects of cannabis is called CB1 and is found primarily in the nervous system. To experience common psychoactive effects, THC must bind to and activate this receptor.

CBD also reacts with the receptorCB1, but a little different. CBDit does not activate it, but actually makes it much more difficult for this receptor to be activated by other compounds. In essence, CBD abolishes the ability of THC to bind to the CB1 receptor and hence the presence of CBD has an important impact on the psychactivity of THC-containing products. Therefore, the ratio of CBD and THC is importantom to estimate what effect will have a hemp product.

Another thing to think about is that most compounds (this applies to CBD) react with many different receptor systems. So, not only is his relationship with THC interesting to CBD, but also his reaction to many other receptors and the effects he may have on all these systems.

CBDwith THC and when only pure CBD?

Basically, yes. CBD can attenuate many THC side effects, jafor example, short-term memory damage or anxiety that occurs especially at higher THC doses. Often it works the more CBD (compared to THC) you have, the fewer side effects you can expect.

THC aAlthough CBDs have different pharmacological properties, they may have similar physiological effects that work through different mechanisms. For example, both compounds may have analgesic and anti-inflammatory effects, but they work through different mechanisms, so that both THC and CBD could potentially increasesew pain relief.

We are already in the research phase when we would be able to be patient-basedto diagnose what combination is best? Or is it finding out what works best for the individual still in trial and error?I don't think there is so much accurate evidence at the moment to tell a patient to take that particular amount for that particular disease. If you find out that a 1: 1 combination of THC with CBD is most helpful to you as a patient, it's great. But most likely, you will get to this point through trial and error. And when you finally get there, you also have to think that this combination may not be right for you forever.

This is because the human physiology sit changes over time, and with it ECS and how densely the receptors are scattered in the body and in the brain. These things change over the course of an individual's life, and so the optimum amount and combination of these compounds is likely to change.

Does it sound that in the long run the right amount can be such a moving target? This can, and therefore it is important, not be too close to a prescribed amount and combination. This topic has been written nteresting study

This is in the worldpharmacy a common thing. Different doses of different drugs can have different effects. Regarding compounds such as CBD that bind to many different receptors, it is true that it is not good to rely on the golden mean. It means that when we double the dose, we should not expect the effect to be twice as strong. In fact, it may be the opposite.

The study also points out that exisdifferent conditions under which different amounts are effective?

Exactly. And probably because CBD in the body binds to so many different receptors. With a small amount of CBD, it hits those receptors to which it is most attracted or those that are most densely distributed. With larger amounts, these receptors saturate, so the rest of the CBD begins to react with other receptor systems, and this is where the various effects begin to develop.

So we really get startedto throw an effective dose of CBD?

It depends on what disease you want to treat. If you are taking CBD for anxiety, there is a so-called golden mean, a moderate amount that has the best effect. With higher amounts, this efficiency may decrease.

But maybe with epilepsyit doesnt happen. Usually, there is a lot of use to treat and I dont think anyone has noticed that with increasing amountsefficiency. But in most clinical studies dealing with epilepsy and similar diseases, CBD is taken orally, in the form of a pill, in large quantities - up to hundreds of milligrams a day. CBD has very low bioavailability, which means that when a person takes a pill, only a small amount of CBD ends up in his bloodstream, which can bind to the nervous system receptors. So when we're talking about the right amount, the way we serve is also important.

So the way you administer can affect how much CBD ends up in an individual's body?

Correctly. Once again, CBD has very low bioavailability. So when you swallow CBD in the form of a pill, only a small fraction of the CBD really gets into the bloodstream and sends signals to the body or brain. Other routes of administration, such as vaporization, sublingual tinctures or transdermal patches, are a more direct route of CBD to the bloodstream. In these ways, a greater amount of CBD can enter the bloodstream. So people who are interested in products with CBD should consider experimenting with different ways of serving. Certain amounts of CBD contained in a pill may not have the same effect as the same amount administered by another route.

Staff, Leafly. "We Asked a Scientist: What's the Right Dose of CBD?" Leafly , 29 June 2018