Across the pet breeders, especially cats and dogs, a new medical trend is spreading - the administration of very small doses of cannabis or only the substance derived from it - CBD (cannabidiol) . The reason for this is most often the effort to relieve the aforementioned pain, inflammation or anxiety. But what do we really know about the mechanism of function of plant, medical cannabinoids if they get into the bodies of our pets? Unfortunately, not much yet. There are a few findings worth mentioning. Decades of neglected research returns and brings interesting statistics.
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As with humans, the use of cannabis in cats and dogs is very complicated. In short, the number of in-depth studies is insufficient, given the absolute certainty of the efficacy and safety of cannabis use for dogs and cats. But the whole thing is starting to gain momentum, and that is true for our four-legged friends. For example, in July of this year, extremely promising results of a study dealing with the use of cannabis -derived CBD for arthritis dogs came to the surface . The results were published in the official international journal "Frontiers of Veterinary Science".
Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs, led by leading doctor Joseph Wakshlag at Cornell University Wakshlag and colleagues they measured the effectiveness of a particular ElleVet Sciences CBD product that they applied to canine subjectsThe goal is to measure how much the drug will be effective against dog pain and their symptoms of arthritis.
However hopeful the results are, there is still only one study, and none of the sensible breeders should decide on one pet in their pet care. Unfortunately, there are not so many of them yet. Fortunately, others are already on the way thanks to the provisional results. Lack of knowledge on this subject is beginning to be absolutely acute and it is obvious that we begin to understand better the political, ethical and scientific implications of studies on the use of cannabis for cats and dogs.
First of all, the following point is worth mentioning: the vast majority of veterinarians cannot afford cannabis as a possible help for your pets, not to mention their personal or professional approach to cannabis issues. Every state has its own laws and more also owns the Veterinary Committee. Even in the healing cannabis mecca itself, California, the California Veterinary Committee's official statement mentions: "There is no prescription in the California Veterinary Act to allow veterinarians to prescribe or recommend cannabis-based medicines in any way to treat animals. violates the law. "
Last year, an interview on this topic was published in the leafy magazine Cannabis Leafly. The editors asked the veterinarian Gary Richter of Oakland what his point of view was. Gary explained that at this time he was working on an online petition called "compassionate care" and aimed at changing the law on the possibility of CBD recommendation for dogs and cats in California, and online petitions have since taken hold and Gary recently announced that the bill is already going through "I am very satisfied with the progress of the process we have achieved since last year," explains Gary. "The law is far from perfect, but everything is going in the right direction."
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Dr. Richter further explains that his enthusiasm and will to enforce a new veterinary law regarding the possibility of prescribing CBD stems from personal experience. "I have had the opportunity to see CBD's efficacy against dog arthritis countless times. However, if today any of us veterinarians can only recommend CBD as possible help, we can face a lifetime cancellation of the veterinary license."
Richter continues to compare human and animal marijuana treatments: "Almost any cannabis treatment that demonstrates therapeutic potential in humans may well be applied to animals. Pain, inflammation, gastrointestinal distress, stress, anxiety, tremors, cancer and so on, we've been able to observe improvements in all of these areas, but if you just mention anything on the subject in front of your office customer, you face potential consequences that may affect the rest of your career. ”
Despite the fact that starting any thorough research into the effects of cannabis is still very problematic, some of the researchers are still not discouraged and the last year of research brings us more promising results.The potential of medical cannabis, and in particular the CBD, is now being encouraged not only by scientists but also by owners of quadruped friends.
Scientific data describing the effects of CBD on canine bodies has been virtually non-existent until recently. Only in April last year did the official veterinary council say: "We are experiencing an acute lack of data describing the effects of cannabis on animals. This shortage is a cause for concern for many veterinarians, as well as a direct consequence of prolonged marijuana prohibition."
The present persistent point of view, which says that medical cannabis for dogs and cats is toxic, is mainly due to events where pets accidentally ingested a large amount of "home supplies" of the owner or owner.
And indeed, a study based on this data concluded that cannabis for dogs was toxic as early as 2004.was that "213 cases of dogs with symptoms of acute cannabis intoxication were recorded between 1998 and 2002. 99% of the animals experienced neurological signs of cannabis intoxication and 30% of them also had negative gastrointestinal symptoms.
The study also describes how these symptoms affect the physical and mental state of the animals. Scientists cite here: "The primary physical symptom of cannabis intoxication in the animals observed was vomiting, depression, tremor, disorientation, hyperactivity, or stiffness." teenagers intentionally blowing cannabis smoke into the faces of their animals.
Since 2000, only a handful of surveys have been conducted to address this phenomenon. Most of them confirmed only one thing and that cannabis for dogs is toxic. The authors of a veterinary study based in Denver Colorado concluded that "Despite the fact that medical cannabis and substances derived from it are generally considered safe, we have seen a few cases of deaths following ingestion of products made from butter with a very high THC concentration.
However, the previous findings did not in any way prevent scientists from making a callkumu continued. In addition, focusing specifically on the effects of CBD for dogs with arthritis has also highlighted its potential functions in human subjects, particularly in terms of dosage and absorption. Other follow-up studies are currently underway. ElleVet Sciences and Dr. Wakshlag, as well as other scientists from the Colorado State University, are already preparing for the next step in overall research.
Prior to the use of CBD for dogs in ElleVet Science, a 1988 study focused on the absorption of CBD in dogs in a pill on an empty stomach was conducted. However, the result was that CBD is poorly absorbed in the dog's stomach and therefore does not offer effective help.
"ElleVet behind us came up with a request to provide a number of experienced researchers who would be for them to look at the function of absorption of medicine rich in cannabinoids, especially after CBD. We also wanted to compare the results of clinical trials," says Dr. Wakshlag at the university. "Right from the start we were very surprised - CBD was absorbed quite effectively in dog bodies. So the result went in contrast to the old study we were talking about. ”
Wakshlad continue to explainsuggests that the resulting CBD absorption was also influenced by pills. While in the old study CBD was in powder form, now scientists began to administer it in gelatin capsules, where CBD was bound to the oil base.
Another challenge for researchers and breeders is, of course, finding effective and safe doses of CBD, suitable for administration to individual animals. If you start your pet blindly serving one of the currently available CBD products, it is not entirely certain that the dose will be sufficient or whether the selected type of "carrier" (eg, oil ) is absorbable at all.
Dr. Wakshlag has prioritized research on the correct dosage of CBD here. The problem here is also the minimally regulated and uncharted market for CBD products, whose manufacturers often claim to be able to help your pets, even though so far there is not enough available study data on how much CBD is actually needed and how to best serve it.
"The dosage we chose for our CBD study is based essentially on the effective amount of CBD that has been observed so far, which has been applied in those few human-based studies.subjects. With regard to body weight, it is therefore assumed that dogs should be treated with approximately the same dose of CBD as for humans. More specifically, it is about 1-5mg per kilogram of body weight, ” Wakshlag explains the tangled situation. "We decided to start from the start below, for two milligrams. We chose 2mg mainly because we want to see if the therapeutic effect is lower and the dose is more affordable for more breeders."
As we mentioned in the previous article "THC or CBD for Dogs and Cats", most veterinarians and current sources of information will tell you to avoid the application of THC to dogs or cats. THC enters the mix with a lot of entanglement.
However, the question of THC toxicity in the case of aftergiving cats or dogs is not yet 100% answered. For example, one of the other veterinarians from Oakland, Gary Richter, firmly believes THC has something to offer to our four-legged friends. Gary decided to go his own way and THC began to investigate (very carefully) his own dog Leo. He chose carefully measured doses of hashish or extract for application. Richter then communicates his findings to other veterinarians and breeders through online seminars and lessons.
" Provisional research is very clear - THC provides some medical benefits , at least as far as it affects humans," explains Richter. "Although THC toxicity has been observed in poisoned dogs and cats, the risk is mainly due to an over-high dose. Of course, our bodies and their weight are completely different from those of dogs, but we have a very similar endocannabinoid system. So it makes no sense for THC to be too toxic to dogs as we talk about it today. ”
"The main concern in my mind is the fact that there are a number of cats, dogs, and pets, who would benefit from the proper application of THC and CBD for significant health benefits. There is a huge amount of drugs that are toxic at poor dosing and However, this does not mean that they cannot be beneficial if used properly. ”
" Nobody criticizes my cabinet full of legal pharmaceuticals. Most of them I could do while injuring dogs badly. Nobody talks about that anymore ... ”">
If we begin to look at the entire problem, according to Dr. Richter, with an objective, scientific eye, we will naturally start to think about the minimum dose causing negative effects in animals. At the moment we find the toxic limit, we can apply carefully measured doses of THC, CBD or both. Of course, it depends on the illness we are trying to cure.
Furthermore, the cannabinoids of pofrom cannabis, they react in the body together with other substances - terpenoids and flavonoids. All reactions between the range of active substances applied in the results need to be known. Charting the interactions of allOf course, these chemical processes are, of course, very complex, and further research is so obvious.
"What is the ideal combination of THC and CBD ratios? Which terpenes to mix in the entire mix and which should be omitted?w.semena-marihuany.cz/en/blog/411-davkovani-lecebneho-konopi-mene-je-vice "> medical potential. However, we still have a number of processes that we do not understand and that need to be thoroughly researched before we can confidently serve our pets with such substances. ”
With caution and safety as factors in the first place, Dr. Richter embarked on his own experiments. And wonderfully, it seems that hemp can also have tremendous potential in the treatment of cats and dogs.
As mentioned above, CBD alone has a very high success rate in the treatment of arthritis in dogs . All 16 dogs that were exposed to CBD during ElleVet research showed positive results and improved fitness. "We even had one dog that we were ready to put to sleep. His symptoms of arthritis were really nasty and without proper treatment, it wouldn't be worth the worry. But two years have passed since the study and guess what - the same dog is now running around the garden and his symptoms of arthritis have been reduced to a minimum. "
However, let's go back to Dr. Richter, who began his own treatment of his dog Leo. Leo suffered a brain injury during a conflict with another dog. Subsequently, Leo had consequences such as tremors and general seizures. After testing a plethora of pharmaceuticals, the doctor turned to cannabidiol. "I couldn't believe it. His tremors and seizures were almost instantaneous," Richter writes on his blog. "Leo was more than a few times a week shivering. Now, with regular CBD oil applications, his seizures will show up to twice a month. ”
As we all see, in the case of cannabis dogs, there is some healing hope that is hardly questionable at this point. However, with regard to the treatment of cats, there is still an acute lack of quality data.
One of the few studies of cannabinoid effects on cats is again a study by ElleVet, which is still trying to find the right cannabinoid blend that could benefit our small beasts. However, research director Howland warns: "Cats are definitely something completely different than a small dog. Their bodies respond to the influence of cannabis fromin a different way. In short, the metabolic process is different. Caution is in place. If the wrong dose is given, THC and CBD can be very toxic to cats. ”
However, it has already been observed that in the case of administration of the correct dose, cannabinoids in cats can, for example, better calm visible anxiety. Of course, breeders are not advised to administer their own cannabis products to cats. The best option here is to wait for the result of ElleVet's ongoing research, which has been eager to take on the task.
Boesch, et al. "Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs." Frontiers , Frontiers, 2 July 2018, www.frontiersin.org/articles/10.3389/fvets.2018.00165/full.
"Figure 2f from: Irimia R, Gottschling M (2016) Taxonomic Revision of Rochefortia Sw. (Ehretiaceae, Boraginales). Biodiversity Data Journal 4: e7720. Https://Doi.org/10.3897/BDJ.4.e7720." : 10.3897 / bdj.4.e7720.figure2f.
Harvey, DJ, et al. "Comparative Metabolism of Cannabidiol in Dog, Rat and Man." Pharmacology, Biochemistry, and Behavior , US National Library of Medicine, Nov. 1991, www.ncbi.nlm.nih.gov/pubmed/1806942.
Adejumo, Adeyinka C., et al. "Cannabis Use Is Associated with Reduced Prevalence of Progressive Stages of Alcoholic Liver Disease."Liver International, John Wiley & Sons, Ltd (10.1111), Feb 10, 2009 2018, onlinelibrary.wiley.com/doi/abs/10.1111/liv.13696.
Articles from category research have only informative in nature. They are not intended to encourage the cultivation or spread of cannabis as a drug, but to raise awareness of cannabis.