What is CBGA?

  • What is CBGA?

CBGA is the basic compound found in cannabis. You could say CBGA is such a "great-grandfather" of cannabinoids. Do you know why?

CBGA is at the peak of the cascade reaction, as it creates three major cannabinoid lines:

- THCA (tetrahydrocannabinolic acid)
- CBDA (cannabidiolic acid)
- CBCA (cannabichromenic acid)


These acids then become THC, CBD or CBC. CBGA is also able to “transform” into CBG, but primarily pulls to THC or CBD.


The birth of CBGA

The existence of CBG (cannabigerol) has been known for over 50 years. Israeli scientists were the first to separate this cananabinoid. Thirty years later, they were followed by Japanese scientists with their discovery that CBGA was his "parent". Despite a long history, however, CBGA has not been subjected to so much research.

Much of the CBGA experiments concerned long-term THCA production for pharmaceutical and research needs. More specifically, these studies focused on the mechanism for converting CBGA to THCA.

This year, the Californian scientific team published a paper on complete cannabinoid synthesis, including CBGA.




Potential health benefits of CBGA
Although very little research has been conducted into health benefits, preliminary studies suggest potential benefits.

Cardiovascular disease

CBGA could help diabetics manage some of the complications and co-morbidities associated with this disease (eg cardiovascular disease). During the CBGA research conducted in the tube, it was found to be able to perfectly suppress an enzyme called aldose reductase, which is the main “generator” of oxidative stress, which leads to heart and other problems.

Synthetic substances suppressing this enzyme cause many side effects, so a CBGA drug could be very beneficial.

Metabolic disorders

Another research team has discovered in CBGA the potential to help with other metabolic disorders. This year's in silico study (computer simulation) was designed to look at the role of CBGA in the activation of peroxisome proliferator receptors (PPARs) that regulate metabolism. If PPAR is not working properly, people will develop diseases: diabetes, high cholesterol, or lipid metabolism disorders. The study demonstrates that CBGA can awaken PPAR receptors, thereby stimulating lipid metabolism. However, more tests on humans and experimental animals are needed.

Colon cancer

Over time, CBGA could become a major fighter against the third most common type of cancer, and that is colon cancer. He's the fourth killer in cancer-related deaths.

Researchers focused on the cytotoxic effects of CBGA and found that not only did it kill cells causing colon cancer, but it would not allow the cancer to break out and close the entire circulation of these cells.

Although more research is needed, researchers are already convinced that CBGA can effectively target not only these cancer-forming cells, but also provide prevention against polyp growth and proliferation. If polyps are not treated, they grow into carcinomas.






Would you like to learn more about other cannabinoids and the endocannabinoid system in general? So check out some of our articles on these topics:

- Introduction to endocannabinoid system
- 7 interesting facts about the endocannabinoid system
- List of all active substances in cannabis
- Why doesn't CBD induce psychoactive states?

Author of article: Jacqueline Havelka
Article source: leafly.com
Photo Sources: pixabay.com (isuru prabath, Pexels), wikipedia.org