Do THCA, CBDA and terpenoids interact?
A mixture of different phytocannabinoids cannabis sativa is more biologically active than a single phytocannabinoid itself. However, cannabinoid terpenoids have not been sufficiently investigated as initiators of phytocannabinoid activity.
The terpenoid groups were statistically associated with certain varieties of cannabis that were rich in tetrahydrocannabinolic acid (THCA) or cannabidiolic acid (CBDA). These groups have the ability to increase the decarboxylation activity of phytocannabinoids (i.e., THC or CBD).
Analytical HPLC and GC / MS were used to identify and determine the amount of second metabolites in 17 cannabis sativa varieties. During this period, the relationship between cannabinoids and terpenoids was determined for each variety.
Column splitting was used to separate and collect the compounds. Chemical analysis of cell viability was used to assess biological activity. We have found that in the “high THC” or “high CBD” varieties, phytocannabinoids are produced along with a certain set of terpenoids. Only related terpenoids improved the cytotoxic activity of phytocannabinoids on the cell lines MDA-MB-231 and HCT-166.
The interrelationship between THCA and CBDA and a particular set of terpenoids can affect cannabis cultivation and may have an impact on the use of therapeutic effects.
Keywords: cannabis sativa, phytocannabinoids, terpenoids, concomitant effect, cancer cell lines
Authors: Hillary Voet, Vinayaka Ajjampura, Stalin Nadarajan, Einav Mayzlish-Gati, Moran Mazuz, Nurit Shalev, Hinanit Koltai.
You can read more of this study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749504/. The whole study is in English.
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