There are many reasons for this disease. It can be caused by viral brain inflammation, trauma or long-term use of some medications. Heredity also plays a role. The disease most often begins around the 55th age of life, mostly unnoticed. Frequent manifestations are tremor or tiredness, stiffness in the limbs and back, cramps, slowed movements and sleep problems. Complete cure is not possible, only the course of the disease can be alleviated. Treatment includes a variety of drugs that supply the missing dopamine. Sometimes brain surgery is also possible.