Are cannabis side effects making you feel bad? The problem might be in your genes...

Some users, however, experience the exact opposite after applying this type of marijuana - an unpleasant feeling of discomfort, psychological distress, and in the worst cases, acute feelings of paranoia and fear. Just like with most drug experiences, the first application is absolutely crucial, which often predetermines the pleasantness or discomfort experienced during future applications. It is quite understandable that if someone takes an excessively high dose of THC for the first time in the company of people with whom they do not feel comfortable even when sober, their experience will not be particularly euphoric, and they will probably not be eager to use it again.

"Let's say, however, that you enjoyed the effects of cannabis for some time, but something changed and the effect of THC suddenly seems intrusive and unpleasant to you. What's going on here?"

Factors Affecting Effect & Impact of Medicinal Cannabis

Of course, there are literally a ton of factors that can influence the resulting effect of marijuana on the body and psyche of the user. The following three factors can be considered absolutely the most important. (Note - we are exclusively discussing the effects of varieties with very high THC content. We do not take into account variable factors such as different terpenes and THC:CBD ratios)

Age: Many people find the effects of cannabis more pleasant during adolescence than in fully adult age

Opioid Receptors: The amount and allocation of opioid receptors in the brain affects the resulting effect of cannabis

CB1 Receptors and Their Location: The type of brain cells containing the most CB1 receptors can dictate whether the experience after cannabis application will be euphoric, or will instead evoke an aversion to it