5 ways to treat Alzheimers disease with cannabis [Study & Research 2019]

5 ways to treat Alzheimers disease with cannabis [Study & Research 2019]
  • THC is able to slow the growth of neuritic plaques
  • THC a CBD acts synergistically in the case of Alzheimers disease
  • New studies show neuroprotective, anti-inflammatory and antioxidant effects of CBD

Natural treatment of Alzheimers disease

Today we look at some of the very promising researches that are trying to bring light into problematic sendocannabinoid system human body and its role in neurodegenerative disorders such as Alzheimers disease.

1. THC slows the growth of neuritic plaques

One of the pathological symptoms typical of Alzheimers disease is the abundance and deposition of beta-amyloid in brain tissue. Salk Research Institute in San Diego has shown that high beta amyloid concentrations are directly proportional to higher cell inflammation and neuronal death.

In 2008, however, came outsurface verypromising studyin a scientific magazine "Molecular Pharmaceutics"that confirms the effect of THC in association with the slowing of beta-amyloid growth . This statement wouldwas reaffirmed in 2014 when a study was published in a scientific magazine "Journal of Alzheimers Disease"that showed similar results.

"Moreover, THC acts as an inhibitor of beta-amyloid formation better than commonly prescribed drugs such as donepezil or tacrine even at lower concentrations."

alzheimerova choroba a alternativní léčba pomocí marihuany či konopí

2. Therapeutic cannabis is anti-inflammatory

The neuritic plaque abundance also increases their inflammation, which further contributes to the deterioration of Alzheimers disease.

Therapeutic tohowever, onopy has known anti-inflammatory properties, confirmed 2006 Studies,when it was confirmed that activation of CB1 receptors (by action) cannabinoids endocannabinoid system) has anti-inflammatory effects.

More official 2012 studyonly contributed to affirming the importance of the endocannabinoid system: "Utest mice that were bred without CB1 receptors have been shown to exhibit much faster degeneration of the cognitive system. "

Souvhowever, the integrity of the endocannabinoid system and neurodegenerative disorders such as Alzheimers disease must be further confirmed by a thorough study conducted on human subjects.

3. CBD helps prevent cell death

THC is not the only active substance in cannabis that can help in the case of neurodegenerative disorders CBD (cannabidiol)

which, unlike THC, is not psychoactive, also offers healing potential, not only in the case of Alzheimers disease.

MohYou should be interested: 8 frequently asked questions about CBD

These results have been reviewed in 2009 study"Cannabidiol as a promising drug for neurogenerative disorders?" when it was dosthe same and further promising results in case of synergy of both THC and CBD. So far researchers have judged carefully, but with the optimism the following:

"In CBD, there is tremendous therapeutic potential whether administered in synergy with or without THC, mainly due to the fact that this unusual, if not unique, compound is able to provide nearly all of the neuroprotective properties that come from Alzheimer's and others neurodegenerative disorders are expected.

In most neurodegenerative disorders, there is some degree of oxidative damage, excitotoxicity (excess glutamate in nerve tissue), inflammation, etc. The CBD can help with all these problems.

Everything is moving in a positive direction, as confirmed by follow-up studies from 2017 . Evidence of a clinical study focusing in particular on the effect of CBD in relation to the occurrence of amyloid plaques indicates that cannabidiol is able to target so-called PPAR-γ receptors.

"Furthermore, during the second phase of clinical research, it was confirmed that the effect of CBD on PPAR-γ receptors was to improve overall cognition in patients."

amyloid plaques, help, natural treatment, prevention, Alzheimer

4. Cannabinoids stimulate cell growth

Moreover, as a plus to all antioxidant and overall neuroprotective properties, it seems that hemp can stimulate cell growth in the hippocampus, a part of the brain associated with memory function.

This mechanismus also known as "nourogenesis "examines in connection with cannabinoids2011 study which notes in particular the "ability of cannabinoids to support the process of self-repair of the brain".

5. Therapeutic cannabis reverses certain symptoms of Alzheimers disease

It should be noted that some of the results of studies in mouse subjects have not yet been fully transferred to human subjects.

NothingHowever, healing marijuana has proven to be very beneficial and the symptoms of reducing the treatment. For example, in a small study where cannabis was administered to ten patients suffering from Alzheimers, it has been shown that the quality of life of patients can be improved within four weeks.

The last and invincible arThe argument here is that cannabis is able to bring Alzheimers sufferers a little relief. The side effects of cannabis treatment bring patients cannabis improve appetite , reducing the feeling of restlessness as well as improving cognition and motor functions.

Healing hemp is a unique plant. Decades of research confirm its therapeutic potential for not only Alzheimers but also:

  • diabetes
  • glaucoma
  • gastrointestinal disorders
  • anorexia

Cannabis varieties for treatmentor Alzheimers disease

According to Leafly.com users feedback, patients focus on varieties:

Resources: 

Eubanks, Lisa M., et al. Molecular Link between the Active Component of Marijuana and Alzheimers Disease Pathology. Molecular Pharmaceutics, vol. 3, no. 6, 2006

Cao, Chuanhai & Li, Yaqiong & Liu, Hui & Bai, Ge & Mayl, Jonathan & Lin; (2014). The Potential Therapeutic Effects of THC on Alzheimer's Disease. Journal of Alzheimer's Disease: JAD. 42. 10.3233 / JAD-140093.

Eubanks, Lisa M., et al. Molecular Link between the Active Component of Marijuana and Alzheimers Disease Pathology. Molecular Pharmaceutics, vol. 3, no. 6, 2006, p. 773-777., Doi: 10.1021 / mp060066m.

Bilkei-Gorzo, A. "The Endocannabinoid System in Normal and Pathological Brain Aging." Philosophical Transactions of the Royal Society B: Biological Sciences , vol. 1607, 2012, s. 3326-3341., Doi: 10.1098 / rstb.2011.0388.

Neuroprotective Effect of Cannabidiol, and Non-Psychoactive ... onlinelibrary.wiley.com/doi/full/10.1111/j.1471-4159.2003.02327.x.

Iuvone, T, et al. "Cannabidiol: a Promising Drug for Neurodegenerative Disorders?" Current Neurology and Neuroscience Reports. , US National Library of Medicine, 2009, www.ncbi.nlm.nih.gov/pubmed/19228180.

Esposito, G, et al. "Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement." Current Neurology and Neuroscience Reports. , US National Library of Medicine, www.ncbi.nlm.nih.gov/pubmed/22163051.

S, Paul, and Shua Haim. "Safety and Efficacy of Dronabinol in the Treatment of Agitation in Patients with Alzheimer's Disease with Anorexia: A Retrospective Chart Review." Cannabis Medicine, www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=61.

Fernández-Ruiz J., González S. (2005) Cannabinoid Control of Motor Function at Basal Ganglia. In: Pertwee RG (eds) Cannabinoids. Handbook of Experimental Pharmacology, vol 168. Springer, Berlin, Heidelberg

JS, Ross, and Shua Haim. "Open-Label Study of Dronabinol in Treatment of Refractory Agitation in Alzheimer's Disease: a Pilot Study." Cannabis Medicine , www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=92.

Watt, G, and T Karl. "Evidence for In Vivo Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease." Current Neurology and Neuroscience Reports. , US National Library of Medicine, 3 Feb. 2017, www.ncbi.nlm.nih.gov/pubmed/28217094.